Aspect Medical Systems and the Brain Resource Company to Collaborate on Mild Cognitive...

NEWTON, Mass. -- Aspect Medical Systems, Inc. (NASDAQ: ASPM) and The Brain Resource Company (BRC) have agreed to collaborate in a multi-year clinical study that will evaluate brain electrical activity in patients identified with mild cognitive impairment (MCI), a memory impairment that often precedes

"BRC has relationships with key centers and influential thought leaders who are conducting research related to MCI. We expect that this access will help expedite the process of gaining more complete information about brain activity throughout the range of cognitive ability," said Philip Devlin, general manager of Aspect's Neuroscience division. "We believe that this information will advance our efforts to develop a brain monitoring index to identify patients with MCI or early stage Alzheimer's disease, to track disease progression over time and to monitor the effectiveness of drug therapies."

Studies have shown that six to 25 percent of patients diagnosed with MCI will progress to Alzheimer's disease each year. Further, four million Americans suffer from Alzheimer's disease and another eight million are estimated to suffer from MCI.

About Aspect's Neuroscience Division

Aspect's Neuroscience Division was founded to expand upon the company's expertise in brain monitoring to improve patient care for people suffering from neurologically-based diseases such as major depressive disorders and Alzheimer's disease. The company entered into a $25 million strategic alliance with Boston Scientific to support the development and commercialization of neuroscience-related products. More information about Aspect's Neuroscience Division can be found at http://www.aspectmedical.com/professionals/neuroscience/.

About Aspect Medical Systems, Inc.

Aspect Medical Systems, Inc. (NASDAQ: ASPM) is a global market leader in brain monitoring technology. To date, the Company's BIS technology has been used to assess more than 13.1 million patients and has been the subject of approximately 2,200 published articles and abstracts. BIS technology is installed in approximately 68 percent of hospitals listed in the July 2005 U.S. News and World Report Ranking of America's Best Hospitals and in approximately 41 percent of all domestic operating rooms. In the last twelve months BIS technology was used in approximately 13 percent of all U.S. surgical procedures requiring general anesthesia or deep sedation. BIS technology is available in more than 160 countries. Aspect Medical Systems has OEM agreements with seven leading manufacturers of patient monitoring systems. The company is also investigating how other methods of analyzing brain waves may aid in the diagnosis and management of neurological diseases, including depression and Alzheimer's disease. For more information, visit Aspect's Web site at http://www.aspectmedical.com.

Safe Harbor Statement

Certain statements in this release are forward-looking and may involve risks and uncertainties, including statements with respect to the Company's ability to successfully develop tools for the diagnosis and treatment of neurological diseases, such as depression and Alzheimer's disease, the benefits of such tools, if developed, for the general population of patients with such diseases and, in particular, mild cognitive impairment and Alzheimer's diseases and the estimated market for such products. There are a number of factors that could cause actual results to differ materially from those indicated by these forward-looking statements. For example, the Company may not be able to successfully develop products for the diagnosis and treatment of neurological diseases, such as depression and Alzheimer's disease, achieve widespread market acceptance of any such products that it may develop or to compete with new products or alternative techniques that may be developed by other. There are additional factors that could cause the Company's actual results to vary from its forward-looking statements, including without limitation those set forth under the heading " Factors Affecting Future Operating Results" in the Company's Quarterly Report on Form 10-Q for the fiscal quarter ended October 1, 2005, as filed with the Securities and Exchange Commission. In addition, any forward-looking statements represent the Company's views only as of the date of this press release and should not be relied upon as representing the Company's views as of any subsequent date. While the Company may elect to update forward-looking statements in the future, it specifically disclaims any obligation to do so, even if its expectations change. Therefore, you should not rely on these forward-looking statements as representing the Company's views as of any date subsequent to the date of this press release.

Aspect, Bispectral Index and BIS are registered trademarks of Aspect Medical Systems, Inc. All other trademarks, service marks and company names are the property of their respective owners.